Regulation of fungal decomposition at single-cell level
نویسندگان
چکیده
منابع مشابه
Gene regulation at the single-cell level.
The quantitative relation between transcription factor concentrations and the rate of protein production from downstream genes is central to the function of genetic networks. Here we show that this relation, which we call the gene regulation function (GRF), fluctuates dynamically in individual living cells, thereby limiting the accuracy with which transcriptional genetic circuits can transfer s...
متن کاملDynamics of epigenetic regulation at the single - cell level
5. L. J. Picker, S. G. Hansen, J. D. Lifson, Annu. Rev. Med. 63, 95–111 (2012). 6. S. G. Hansen et al., Science 340, 1237874 (2013). 7. S. G. Hansen et al., Nature 473, 523–527 (2011). 8. S. G. Hansen et al., Nature 502, 100–104 (2013). 9. R. W. Wiseman et al., Nat. Med. 15, 1322–1326 (2009). 10. N. Lee, D. R. Goodlett, A. Ishitani, H. Marquardt, D. E. Geraghty, J. Immunol. 160, 4951–4960 (1998...
متن کاملDynamics of epigenetic regulation at the single-cell level.
Chromatin regulators play a major role in establishing and maintaining gene expression states. Yet how they control gene expression in single cells, quantitatively and over time, remains unclear. We used time-lapse microscopy to analyze the dynamic effects of four silencers associated with diverse modifications: DNA methylation, histone deacetylation, and histone methylation. For all regulators...
متن کاملRegulation of alternative splicing at the single‐cell level
Alternative splicing is a key cellular mechanism for generating distinct isoforms, whose relative abundances regulate critical cellular processes. It is therefore essential that inclusion levels of alternative exons be tightly regulated. However, how the precision of inclusion levels among individual cells is governed is poorly understood. Using single-cell gene expression, we show that the pre...
متن کاملHaplotype resolution at the single-cell level.
One of the most rapidly advancing areas in genomics in recent years has been the explosion of platforms to assess properties at the single-cell level. The driving force behind these advancements has been a renaissance of sorts in how we think about the architecture and heterogeneity present in a population of cells (1, 2). While these concepts are not new, the advancement of technologies to ass...
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ژورنال
عنوان ژورنال: The ISME Journal
سال: 2020
ISSN: 1751-7362,1751-7370
DOI: 10.1038/s41396-019-0583-9